4-Chlorobenzoyl chloride → HCID 178513170、化合物
反応式
C(=O)(O)O.[NH:5]([C:7](=[NH:9])[NH2:8])[NH2:6].[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1>N1C=CC=CC=1.C(Cl)Cl>[Cl:10][C:11]1[CH:19]=[CH:18][C:14]([C:15]([NH:6][NH:5][C:7](=[NH:8])[NH2:9])=[O:16])=[CH:13][CH:12]=1参加物
5
反応条件
- 温度
- 15 °C
実験手順
To a solution of hydrazinecarboximidamide bicarbonate salt (2.3 g, 31.05 mmol) in pyridine (70 ml) was added dropwise 4-chlorobenzoyl chloride (4.5 g, crude) in DCM (20 ml). After stirring overnight at 15° C., the resulting mixture was concentrated under vacuum, quenched by the addition of water (20 ml) and adjusted to pH 13 with sodium hydroxide solution (10N). The product was collected by filtration and dried to give 2-(4-chlorobenzoyl)hydrazinecarboximidamide as a white solid (2.1 g, crude).
後処理
- concentrationthe resulting mixture was concentrated under vacuum
- customquenched by the addition of water (20 ml)
- filtrationThe product was collected by filtration
- customdried
出典と根拠
- ORDレコード
- ord-9c6f445d54624a0a8bf67b37052a1dae
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278973B2
反応ノート
読み込み中…