Methanol → 5-(Methoxymethyl)pyridine-2,3-dicarboxylic acid

HRID 923361ノート

反応式

HRID 923361 の反応式
Cl[CH2:2][C:3]1[CH:4]=[C:5]2[C:12](=[O:13])[O:11][C:9](=[O:10])[C:6]2=[N:7][CH:8]=1.[CH3:14][OH:15].[OH-:16].[Na+]>>[CH3:14][O:15][CH2:2][C:3]1[CH:4]=[C:5]([C:12]([OH:11])=[O:13])[C:6]([C:9]([OH:16])=[O:10])=[N:7][CH:8]=1

参加物

4

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 46899675HCID 46899675、化合物

生成物 1

HCID 109983115-(Methoxymethyl)pyridine-2,3-dicarboxylic acid

実験手順

7.0 g (35 mmol) 5-chloromethyl-2,3-pyridinedicarboxylic acid anhydride were dissolved in 165 g (5.16 mol) methanol at room temperature, causing formation of monoesters. 14 g (350 mmol) NaOH (50% in water) were slowly added whereupon the temperature rose to 50° C. and carboxylate started to precipitate. Stirring was continued for additional 5 hrs at 65° C.

後処理

  1. customrose to 50° C.
  2. customto precipitate

出典と根拠

ORDレコード
ord-c57cf6fd58c74b67bf71faf6a85ee8d8
出典データセット
uspto-grants-2016_03
特許番号
US09278977B2

反応ノート

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