Trifluoroacetic acid → (S)-3,3-dimethyl-2-(((S)-tetrahydrofuran-3-yloxy)carbonylamino)butanoic acid
反応式
[CH3:1][C:2]([CH3:21])([CH3:20])[C@H:3]([NH:11][C:12]([O:14][C@H:15]1[CH2:19][CH2:18][O:17][CH2:16]1)=[O:13])[C:4]([O:6]C(C)(C)C)=[O:5].FC(F)(F)C(O)=O>ClCCl>[CH3:1][C:2]([CH3:21])([CH3:20])[C@H:3]([NH:11][C:12]([O:14][C@H:15]1[CH2:19][CH2:18][O:17][CH2:16]1)=[O:13])[C:4]([OH:6])=[O:5]参加物
4
実験手順
To a solution of the product from Example 59A (0.037 g, 0.123 mmol) in dichloromethane (1.2 mL) was added trifluoroacetic acid (1.2 mL) and the mixture was stirred at room temperature for 2 hours. The solvent was evaporated to give the title compound which was used without further purification.
後処理
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-79bb69b42a1c4c17930a23e54da0c44c
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278922B2
反応ノート
読み込み中…