Formaldehyde → HCID 118308739、化合物

反応式

[N+:1]([CH:4]([C:6]1[CH:15]=[CH:14][C:9]([C:10](OC)=[O:11])=[CH:8][CH:7]=1)[CH3:5])([O-:3])=[O:2].[CH2:16]=[O:17].C[O-].[Na+].[Cl-].[NH4+].CN([CH:26]=[O:27])C>>[OH:17][CH2:16][C:4]([C:6]1[CH:7]=[CH:8][C:9]([C:10]([O:27][CH3:26])=[O:11])=[CH:14][CH:15]=1)([N+:1]([O-:3])=[O:2])[CH3:5]

参加物

反応物 5

HCID 712Formaldehyde

HCID 6228Dimethylformamide

HCID 25517Ammonium Chloride

HCID 10942334Sodium Methoxide

HCID 11310314Benzoic acid, 4-(1-nitroethyl)-, methyl ester

生成物 1

HCID 118308739HCID 118308739、化合物

実験手順

To a mixture of 1.44 g of methyl 4-(1-nitroethyl)benzoate and 29 ml of DMF were added 612 mg of paraformaldehyde and 150 mg of sodium methoxide, followed by stirring at room temperature for 18 hours. To the reaction mixture was added a saturated aqueous ammonium chloride solution, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and the solvent was then evaporated. The obtained residue was purified by silica gel column chromatography to obtain 730 mg of methyl 4-(1-hydroxy-2-nitropropan-2-yl)benzoate.