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Diisopropylethylamine → H-Gln(Trt)-Thr-Leu

HRID 923724
ノート
印刷プレビュー

反応式

HRID 923724 の反応式
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:27](O)=[O:28])[CH2:3][CH2:4][C:5](=[O:26])[NH:6][C:7]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1.CCN(C(C)C)C(C)C.[NH2:83][C@H:84]([C:88]([NH:90][C@H:91]([C:96]([OH:98])=[O:97])[CH2:92][CH:93]([CH3:95])[CH3:94])=[O:89])[C@@H:85]([CH3:87])[OH:86]>CN(C=O)C>[NH2:1][C@H:2]([C:27]([NH:83][C@H:84]([C:88]([NH:90][C@H:91]([C:96]([OH:98])=[O:97])[CH2:92][CH:93]([CH3:94])[CH3:95])=[O:89])[C@@H:85]([CH3:87])[OH:86])=[O:28])[CH2:3][CH2:4][C:5](=[O:26])[NH:6][C:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 7021828Thr-LeuHCID 10919157(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-[(triphenylmethyl)carbamoyl]butanoic acid

生成物 1

HCID 131731099H-Gln(Trt)-Thr-Leu

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

In an RBF were mixed Fmoc-Gln(Trt)-OH (44.7 g, 73.2 mmol), BOP (40.4 g, 91.5 mmol) and 250 ml of DMF. The mixture was stirred for 2 min and then DIPEA (18.9 g, 146.4 mmol) was added. The resulting mixture was added in one portion to the pre-swollen H-Thr-Leu-Resin and the reaction mixture was stirred for 2.5 h, the Kaiser test was negative, then the reaction was considered to be complete and the reaction medium was removed via filtration.

後処理

  1. stirringthe reaction mixture was stirred for 2.5 h
  2. customthe reaction medium was removed via filtration

出典と根拠

ORDレコード
ord-bccc98b0463b4e9f830c0839490071ec
出典データセット
uspto-grants-2016_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09278997B2

反応ノート

読み込み中…

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