Nitric Acid → N-Methyl-3-nitro-5-(trifluoromethyl)pyridin-2-amine
反応式
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][N:4]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>O>[CH3:1][NH:2][C:3]1[C:8]([N+:18]([O-:20])=[O:19])=[CH:7][C:6]([C:9]([F:12])([F:10])[F:11])=[CH:5][N:4]=1参加物
5
反応条件
- 温度
- 80 °C
実験手順
To a mixture of N-methyl-(5-trifluoromethyl-pyridin-2-yl)-amine (17.3 g) and sulfuric acid (100 ml), nitric acid (12.3 g) was added drop-wise, and stirred with heating at 80° C. for 2 hours. The mixture was cooled to room temperature, and then the reaction mixture was poured into water. The precipitate was collected by filtration, washed with water, and dried under reduced pressure to give 18.8 g of N-methyl-(3-nitro-5-trifluoromethyl-pyridin-2-yl)-amine.
後処理
- additionwas added drop-wise
- temperatureThe mixture was cooled to room temperature
- filtrationThe precipitate was collected by filtration
- washwashed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-7ec808fd21c542bfbe744b8c65ea6091
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09278983B2
反応ノート
読み込み中…