2-(Methylamino)ethanol → 5-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide

HRID 924029

反応式

HRID 924029 の反応式
[Br:1][C:2]1[C:3](Cl)=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([Cl:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8].[CH3:23][NH:24][CH2:25][CH2:26][OH:27]>>[Br:1][C:2]1[C:3]([N:24]([CH2:25][CH2:26][OH:27])[CH3:23])=[N:4][CH:5]=[C:6]([CH:21]=1)[C:7]([NH:9][C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17]([Cl:20])([F:19])[F:18])=[CH:12][CH:11]=1)=[O:8]

参加物

3

反応物 2

HCID 80162-(Methylamino)ethanolHCID 725460895-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide

生成物 1

HCID 899067025-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-((2-hydroxyethyl)(methyl)amino)nicotinamide

実験手順

The title compound was prepared in an analogous fashion to that described in Stage 33.1 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 169.2) and 2-methylamino-ethanol to afford as a white crystalline solid. HPLC (Condition 4) tR=5.72 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=452.2 [M+H]+.

後処理

  1. customto afford as a white crystalline solid

出典と根拠

ORDレコード
ord-5443036183fc489c9d23936be8d34255
出典データセット
uspto-grants-2016_03
特許番号
US09278981B2

関連ノート

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