Water → tert-Butyl methyl {(3R,4S,5S)-1-[3-({[3-{[(benzyloxy)carbonyl]amino}-7-(3,6-dihydro-2H-pyran-4-yl)quinolin-2-yl]carbonyl}amino)pyridin-4-yl]-5-methylpiperidine-3, 4-diyl}biscarbamate

反応式

CC1(C)C(C)(C)OB([C:9]2[CH2:10][CH2:11][O:12][CH2:13][CH:14]=2)O1.[O-]P([O-])([O-])=O.[K+].[K+].[K+].[CH2:24]([O:31][C:32]([NH:34][C:35]1[C:36]([C:46]([NH:48][C:49]2[CH:50]=[N:51][CH:52]=[CH:53][C:54]=2[N:55]2[CH2:60][C@H:59]([CH3:61])[C@H:58]([NH:62][C:63](=[O:66])[O:64][CH3:65])[C@H:57]([NH:67][C:68](=[O:74])[O:69][C:70]([CH3:73])([CH3:72])[CH3:71])[CH2:56]2)=[O:47])=[N:37][C:38]2[C:43]([CH:44]=1)=[CH:42][CH:41]=[C:40](Br)[CH:39]=2)=[O:33])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.O>O1CCOCC1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C(C(C)C)=CC(C(C)C)=CC=2C(C)C)CCCCC1.NC1C=CC=CC=1C1C=CC=CC=1[Pd]Cl>[CH2:24]([O:31][C:32]([NH:34][C:35]1[C:36]([C:46]([NH:48][C:49]2[CH:50]=[N:51][CH:52]=[CH:53][C:54]=2[N:55]2[CH2:60][C@H:59]([CH3:61])[C@H:58]([NH:62][C:63](=[O:66])[O:64][CH3:65])[C@H:57]([NH:67][C:68](=[O:74])[O:69][C:70]([CH3:73])([CH3:72])[CH3:71])[CH2:56]2)=[O:47])=[N:37][C:38]2[C:43]([CH:44]=1)=[CH:42][CH:41]=[C:40]([C:9]1[CH2:10][CH2:11][O:12][CH2:13][CH:14]=1)[CH:39]=2)=[O:33])[C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1