Hydrochloric Acid → 2-Fluoro-4-formyl-6-hydroxybenzoic acid

HRID 924662ノート

反応式

HRID 924662 の反応式
[F:1][C:2]1[CH:11]=[C:10]([CH:12]=[O:13])[CH:9]=[C:8]([OH:14])[C:3]=1[C:4]([O:6]C)=[O:5].[OH-].[Na+].Cl.CCO>CO>[F:1][C:2]1[CH:11]=[C:10]([CH:12]=[O:13])[CH:9]=[C:8]([OH:14])[C:3]=1[C:4]([OH:6])=[O:5]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 86669343Methyl 2-fluoro-4-formyl-6-hydroxybenzoate2 回

生成物 1

HCID 866815012-Fluoro-4-formyl-6-hydroxybenzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
20 °C

実験手順

A mixture of methyl 2-fluoro-4-formyl-6-hydroxybenzoate (Intermediate 7) (300 mg, 1.50 mmol) and aqueous NaOH (2 M, 10 mL) in MeOH (10 mL) was stirred at 20° C. for 5 hours. The mixture was acidified with aqueous HCl until pH=2 followed by a standard aqueous/EtOH workup. The residue was used for next step without further purification.

後処理

  1. customThe residue was used for next step without further purification

出典と根拠

ORDレコード
ord-ad1ccf40f5e240cf85ac44fdce450753
出典データセット
uspto-grants-2016_03
特許番号
US09283213B2

反応ノート

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