Trifluoroacetic acid → Trifluoroacetic acid
反応式
[O:1]=[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]([CH2:12][CH:13]2[CH2:18][N:17](C(OCC3C=CC=CC=3)=O)[CH2:16][CH2:15][N:14]2C(OC(C)(C)C)=O)=[N:4][NH:3]1.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]>>[NH:14]1[CH2:15][CH2:16][NH:17][CH2:18][CH:13]1[CH2:12][C:5]1[C:6]2[CH2:7][CH2:8][CH2:9][CH2:10][C:11]=2[C:2](=[O:1])[NH:3][N:4]=1.[F:36][C:37]([F:42])([F:41])[C:38]([OH:40])=[O:39]参加物
4
実験手順
A solution of EXAMPLE 258 (35 mg, 0.1 mmol) in trifluoroacetic acid (5 ml) was stirred at room temperature for 1 hour, and was concentrated. The residue was purified by HPLC (Zorbax® C-18 ODS packing material [Agilent Technologies, Santa Clara, Calif.], 0.1% trifluoroacetic acid/CH3CN/H2O) to provide the title compound as a trifluoroacetic acid salt. MS (DCI/NH3) m/z 249 (M+H)+.
後処理
- concentrationwas concentrated
- customThe residue was purified by HPLC (Zorbax® C-18 ODS packing material [Agilent Technologies, Santa Clara, Calif.], 0.1% trifluoroacetic acid/CH3CN/H2O)