Malonic acid, bromoethyl-, diethyl ester → 5-Thiazolecarboxylic acid, 4-hydroxy-2-methyl-, ethyl ester
反応式
C(O[C:4](=[O:14])[C:5](CC)(Br)[C:6]([O:8][CH2:9][CH3:10])=[O:7])C.[C:15]([NH2:18])(=[S:17])[CH3:16]>C1(C)C=CC=CC=1>[CH2:9]([O:8][C:6]([C:5]1[S:17][C:15]([CH3:16])=[N:18][C:4]=1[OH:14])=[O:7])[CH3:10]参加物
4
実験手順
A mixture of ethyl 2-bromo-propanedioic acid diethyl ester (32.0 g, 133.2 mmol) and thioacetamide (10.0 g, 133.2 mmol) in toluene (130 ml) is refluxed for 4 h and then cooled. The insoluble material is filtered off and the filtrate is concentrated. The residue is suspended in diisopropyl ether and collected by filtration to give the 4-hydroxy-2-methyl-thiazole-5-carboxylic acid ethyl ester (7.2 g, 38.5 mmol, 29%).
後処理
- temperatureis refluxed for 4 h
- temperaturecooled
- filtrationThe insoluble material is filtered off
- concentrationthe filtrate is concentrated
- filtrationcollected by filtration
出典と根拠
- ORDレコード
- ord-5dbf06f391604422b05bea8972f2cffa
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284286B2
反応ノート
読み込み中…