Sodium Azide → 3-(3-azidopropyl)-5-chloro-1H-indole

HRID 925307ノート

反応式

HRID 925307 の反応式
Br[CH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([Cl:14])[CH:12]=2)[NH:7][CH:6]=1.[N-:15]=[N+:16]=[N-:17].[Na+]>CN(C=O)C>[N:15]([CH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([Cl:14])[CH:12]=2)[NH:7][CH:6]=1)=[N+:16]=[N-:17]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 668318443-(3-bromopropyl)-5-chloro-1H-indole

生成物 1

HCID 866993903-(3-azidopropyl)-5-chloro-1H-indole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 3-(3-Bromopropyl)-5-chloro-1H-indole (0.730 g; 2.68 mmol) and sodium azide (0.522 g; 8.03 mmol) was stirred in DMF (5 mL) for 18 hours and was then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. After separation, the organic layer was dried over magnesium sulphate and the volatiles were evaporated under reduced pressure to yield quantitatively 3-(3-Azidopropyl)-5-chloro-1H-indole as an oily residue which was used without purification.

後処理

  1. concentrationwas then concentrated under reduced pressure
  2. customThe residue was partitioned between water and dichloromethane
  3. customAfter separation
  4. dry with materialthe organic layer was dried over magnesium sulphate
  5. customthe volatiles were evaporated under reduced pressure

出典と根拠

ORDレコード
ord-0f02a9ee8a9e4707b8b5de880445fb71
出典データセット
uspto-grants-2016_03
特許番号
US09284271B2

反応ノート

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