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Sodium Carbonate → 2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Lithium Chloride | HCID 433294 | — |
| 反応物 | 4-(Triethylsilyl)-3-butyn-1-ol | HCID 2760694 | — |
| 反応物 | 2-Iodo-4-(trifluoromethyl)aniline | HCID 2783322 | — |
| 触媒 | Palladium Chloride | HCID 24290 | — |
| 触媒 | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol | HCID 66832009 | 61.3% |
反応手順
2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol was prepared according to method D Step II with 2-iodo-4-(trifluoromethyl)aniline (1.0 g; 3.48 mmol), 4-(triethylsilyl)but-3-yn-1-ol (0.807 mL; 3.83 mmol), Bis(diphenylphosphino)ferrocene]palladium(II) chloride (0.142 g; 0.174 mmol), lithium chloride (0.147 g; 3.48 mmol) and sodium carbonate (0.738 g; 6.97 mmol) in DMF (10 mL). The crude mixture was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to afford 0.733 g (61%) of 2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09284271B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-9f91656bdf814a65b79f4f5818bc3787 |
| 出典メモ | uspto-grants-2016_03 |