反应详情

2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol was prepared according to method D Step II with 2-iodo-4-(trifluoromethyl)aniline (1.0 g; 3.48 mmol), 4-(triethylsilyl)but-3-yn-1-ol (0.807 mL; 3.83 mmol), Bis(diphenylphosphino)ferrocene]palladium(II) chloride (0.142 g; 0.174 mmol), lithium chloride (0.147 g; 3.48 mmol) and sodium carbonate (0.738 g; 6.97 mmol) in DMF (10 mL). The crude mixture was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane) to afford 0.733 g (61%) of 2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol as a yellow oil.

1. custom2-(2-(triethylsilyl)-5-(trifluoromethyl)-1H-indol-3-yl)ethanol was prepared
2. customThe crude mixture was purified by flash chromatography on silica gel (eluent 2 to 40% ethyl acetate in heptane)