Triethylamine → N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide

HRID 925332

反応式

HRID 925332 の反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH2:14].[O:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][N:22]=2)[CH2:17][CH2:16]1.C(N(CC)CC)C>ClCCl>[Cl:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[NH:8][CH:7]=[C:6]2[CH2:12][CH2:13][NH:14][C:25](=[O:26])[C:24]1[CH:28]=[CH:29][C:21]([N:18]2[CH2:17][CH2:16][O:15][CH2:20][CH2:19]2)=[N:22][CH:23]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 27764616-Morpholinonicotinoyl ChlorideHCID 28274945-Chloro-1H-indole-3-ethylamine monohydrochloride

生成物 1

HCID 67972953N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide収率 57%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide was obtained following Method C starting from 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.042 g, 0.178 mmol), 6-morpholinonicotinoyl chloride (0.045 g; 0.178 mmol), and triethylamine (0.062 mL; 0.446 mmol) in dichloromethane (5 mL). Flash chromatography on silica gel (eluent 1 to 10% methanol in dichloromethane) furnished 0.039 g (57%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-6-morpholinonicotinamide as a solid.

出典と根拠

ORDレコード
ord-da783714262d4fa3aa320c7d4195c129
出典データセット
uspto-grants-2016_03
特許番号
US09284271B2

関連ノート

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