Chloroacetyl chloride → 2-chloro-N-(4-cyanophenyl)acetamide
反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl:17][CH2:18][C:19](Cl)=[O:20]>C(Cl)Cl>[Cl:17][CH2:18][C:19]([NH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1)=[O:20]参加物
5
反応条件
- 温度
- 26 °C
実験手順
A mixture of 4-Amino benzonitrile (1.0 g, 0.0084 mol) and triethyl amine (1 ml, 0.010 mol) was taken in DCM (15 ml). Chloro acetyl chloride (0.67 ml, 0.0084 mol) was added slowly and stirred for 22 hours at 25-27° C. Solvent was removed and the residue was dissolved in ethyl acetate (20 ml), washed with water (1×15 ml) followed by brine (2×15 ml). The organic layer was dried over Na2SO4 and the solvent was removed to get pure 2-chloro-N-(4-cyano-phenyl)-acetamide (1.51 g, 92%).
後処理
- customSolvent was removed
- dissolutionthe residue was dissolved in ethyl acetate (20 ml)
- washwashed with water (1×15 ml)
- dry with materialThe organic layer was dried over Na2SO4
- customthe solvent was removed
出典と根拠
- ORDレコード
- ord-14b0d287f22342c3a097ca881321c7b7
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284316B2
反応ノート
読み込み中…