Ethyl 4,6-dimethoxypyrimidine-2-carboxylate → 4,6-Dimethoxypyrimidin-2-carboxylic acid amide

HRID 925989

反応式

HRID 925989 の反応式
C([O:3][C:4]([C:6]1[N:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]([O:14][CH3:15])[N:7]=1)=O)C.[NH3:16].CO>>[CH3:15][O:14][C:8]1[CH:9]=[C:10]([O:12][CH3:13])[N:11]=[C:6]([C:4]([NH2:16])=[O:3])[N:7]=1

参加物

3

反応物 2

HCID 4449183Ethyl 4,6-dimethoxypyrimidine-2-carboxylateHCID 21705897Ammonia methanol

生成物 1

HCID 582826824,6-Dimethoxypyrimidin-2-carboxylic acid amide収率 100%

実験手順

Ethyl-4,6-dimethoxy-pyrimidin-2-carboxylate (25 g, 1 eq.) in NH3/MeOH (7 M, 15 mL) was irradiated in a microwave reactor at 100° C. for 15 min. The solution was concentrated in vacuo to yield compound 286 as a beige solid in 100% yield. MS (ESI, EI+): m/z=184 (MH+).

後処理

  1. concentrationThe solution was concentrated in vacuo

出典と根拠

ORDレコード
ord-d5485e8e3cc54ecd98714dbc1ec745d5
出典データセット
uspto-grants-2016_03
特許番号
US09284307B2

関連ノート

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