反応式
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]2[C:13]3[N:14]=[CH:15][C:16]([CH:18]4[CH2:20][O:19]4)=[CH:17][C:12]=3[C:11]3=[N:21][CH:22]=[N:23][N:10]3[C:9]2=[O:24])=[CH:5][CH:4]=1.ClC1C=CC=[C:30]([C:34]([O:36]O)=O)C=1.COC1C=C[C:43]([CH2:44][N:45]2C3N=CC(C=C)=CC=3C3=NC=NN3C2=O)=CC=1.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[OH:19][CH:18]([C:16]1[CH:15]=[N:14][C:13]2[N:8]([CH2:7][C:6]3[CH:25]=[CH:26][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[C:9](=[O:24])[N:10]3[N:23]=[CH:22][N:21]=[C:11]3[C:12]=2[CH:17]=1)[CH2:20][N:45]1[CH2:30][CH2:34][O:36][CH2:43][CH2:44]1参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
6-(4-Methoxybenzyl)-9-(oxiran-2-yl)pyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one. 3-Chloroperbenzoic acid (139 mg, 0.62 mmol) was added to a stirred solution of 6-(4-methoxybenzyl)-9-vinylpyrido[3,2-e][1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one (Example 30, 138 mg, 0.41 mmol) in DCM (1.3 mL) and the mixture was stirred for 18 h. Saturated sodium bicarbonate (3 mL) was added to the reaction mixture and the mixture was stirred for 2 h. The reaction mixture was diluted with DCM (5 mL), and the organic layer was separated, dried (MgSO4), and concentrated under vacuum to afford the title compound (118 mg, 82%) as a yellow semi-solid, which was used without further purification in the next step.
後処理
- stirringthe mixture was stirred for 2 h
- customthe organic layer was separated
- dry with materialdried (MgSO4)
- concentrationconcentrated under vacuum
出典と根拠
- ORDレコード
- ord-42d1fde8c5de4b68acb5a1cece9d55a0
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09284335B2
関連ノート
読み込み中…