Trifluoroacetic acid → HCID 62329121、化合物

反応式

Cl.[CH:2]1([CH2:5][O:6][CH:7]2[CH2:11][CH2:10][NH:9][CH2:8]2)[CH2:4][CH2:3]1.FC(F)(F)C(O)=O>>[CH2:5]([O:6][CH:7]1[CH2:11][CH2:10][NH:9][CH2:8]1)[CH:2]([CH3:4])[CH3:3]

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 45075448HCID 45075448、化合物

生成物 1

HCID 62329121HCID 62329121、化合物

実験手順

The compound as its trifluoroacetic acid salt was obtained from (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester following a reaction sequence according to the synthesis of comp. no. 22a. Trifluoroacetic acid was used instead of hydrogen chloride in the final deprotection. LC/MS (method 5): Rt=0.78 min; m/z=144.2 (M+H+).

後処理

customaccording to the synthesis of comp

出典と根拠

ORDレコード: ord-cd698441b8e24480b890565374e4a2f3
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09284333B2

反応ノート

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