Methyl Palmitate → Methylether Palmitate

HRID 926423

反応式

HRID 926423 の反応式
C[O:2][C:3](=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:20][O:21][CH3:22]>>[C:3]([OH:19])(=[O:2])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH3:20][O:21][CH3:22]

参加物

3

反応物 2

HCID 8181Methyl PalmitateHCID 8254Dimethyl Ether

生成物 1

HCID 89413832Methylether Palmitate

反応条件

温度
65 °C

実験手順

Palmitic acid methyl ester (2.00 g; 7.40 mmol) was combined with poly(ethylene glycol) (PEG-12) monomethyl ether 550 (4.41 g; 7.40 mmol; 1.0 equiv) having an average molecular weight of 596 (available from Sigma-Aldrich Chemical Company) in a 40-milliliter vial equipped with a magnetic stir bar. Immobilized Candida antarctica lipase B immobilized on a porous fluoropolymer support as described in US published Patent Application 2012/0040395 was added to the flask in an amount of 0.13 grams, (2 wt % based on the total weight of starting materials). The mixture was stirred and heated to 65° C. and purged with a subsurface stream of nitrogen at a rate of 100 mL/min. After 24 hours a final sample was removed and analyzed by GC to determine conversion of methyl palmitate to palmitic acid methyl ester ethoxylate. Conversion was as follows: after 3 hours, 64.8%; after 6 hours, 80.8%, after 12 hours, 92.1%; and after 23 hours, 96.4%.

後処理

  1. customvial equipped with a magnetic stir bar
  2. additionwas added to the flask in an amount of 0.13 grams
  3. custompurged with a subsurface stream of nitrogen at a rate of 100 mL/min
  4. customAfter 24 hours a final sample was removed
  5. waitafter 6 hours
  6. wait80.8%, after 12 hours
  7. waitand after 23 hours

出典と根拠

ORDレコード
ord-b364cf90193c4827a39d61ad3a177e25
出典データセット
uspto-grants-2016_03
特許番号
US09284583B2

関連ノート

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