Oxalyl chloride → 7-chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl adamantanecarboxylate

HRID 926440ノート

反応式

HRID 926440 の反応式
[C:1]12([C:11]([O:13][CH:14]3[CH:18]4[O:19][C:20](=[O:26])[CH:21]5[CH:22]([C:23](O)=[O:24])[CH:15]3[CH2:16][CH:17]45)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.C(Cl)(=O)C([Cl:30])=O>C1(C)C=CC=CC=1>[C:1]12([C:11]([O:13][CH:14]3[CH:18]4[O:19][C:20](=[O:26])[CH:21]5[CH:22]([C:23]([Cl:30])=[O:24])[CH:15]3[CH2:16][CH:17]45)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 1181291646-adamantanecarbonyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-7-carboxylic acid

生成物 1

HCID 1181291597-chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furan-6-yl adamantanecarboxylate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

In 420 ml of toluene was suspended 60 g of the carboxylic acid (23) obtained in Synthesis Example 1-1-2. At 80° C., 25.3 g of oxalyl dichloride was added dropwise to the suspension, which was stirred for 4 hours. The toluene was distilled off in vacuum, obtaining the target compound. The resulting acid chloride was used in the subsequent reaction without further purification.

後処理

  1. customobtained in Synthesis Example 1-1-2
  2. distillationThe toluene was distilled off in vacuum
  3. customobtaining the target compound

出典と根拠

ORDレコード
ord-85b39fa95c7a4c359bd7c0acf163ab2a
出典データセット
uspto-grants-2016_03
特許番号
US09285678B2

反応ノート

読み込み中…