Methanol → Methyl 3-(trifluoromethyl)benzoate

HRID 926833

反応式

HRID 926833 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([OH:8])=[O:7].S(Cl)(Cl)=O.[CH3:18]O>>[F:1][C:2]([F:12])([F:13])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([O:8][CH3:18])=[O:7]

参加物

4

反応物 3

HCID 887MethanolHCID 99633-(Trifluoromethyl)benzoic acidHCID 24386Thionyl Chloride

生成物 1

HCID 520213Methyl 3-(trifluoromethyl)benzoate収率 86%

反応条件

温度
75 °C

実験手順

To a solution of 3-(trifluoromethyl)benzoic acid (5 g, 26.30 mmol, 1.00 equiv) in methanol (25 mL) was added dropwise thionyl chloride (9.39 g, 78.93 mmol, 3.00 equiv) and the resulting solution was stirred for 2 h at 75° C. in an oil bath. The mixture was concentrated under vacuum, diluted with 100 mL of ethyl acetate and then washed with 2×30 mL of sodium carbonate and 2×30 mL of brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum to yield 4.6 g (86%) of methyl 3-(trifluoromethyl)benzoate as yellow oil

後処理

  1. concentrationThe mixture was concentrated under vacuum
  2. additiondiluted with 100 mL of ethyl acetate
  3. washwashed with 2×30 mL of sodium carbonate and 2×30 mL of brine
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-deb3073d0df04051919e764db1f98a0d
出典データセット
uspto-grants-2016_03
特許番号
US09289430B2

関連ノート

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