1-(3,4-dimethylphenyl)-3-nitro-1H-pyrazole → 1-(3,4-dimethylphenyl)-1H-pyrazol-3-amine
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8]>CO.C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8]参加物
4
実験手順
Into a 100-mL round bottom flask, was placed a solution of 1-(3,4-dimethylphenyl)-3-nitro-1H-pyrazole (900 mg, 4.15 mmol, 1.00 equiv) in methanol/ethyl acetate (20/10 mL). The solution was treated with Pd/C (500 mg) and stirred under an atmosphere of hydrogen overnight at room temperature. The reaction progress was monitored by LCMS. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 750 mg (97%) of 1-(3,4-dimethylphenyl)-1H-pyrazol-3-amine as a yellow solid.
後処理
- customInto a 100-mL round bottom flask, was placed
- filtrationThe solids were filtered out
- concentrationThe resulting mixture was concentrated under vacuum
出典と根拠
- ORDレコード
- ord-e9fee79c56734419b4d2f9ad3c0837ad
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09289430B2
反応ノート
読み込み中…