2-Fluoro-5-iodotoluene → 3,4-Bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine

HRID 927082

反応式

HRID 927082 の反応式
[CH2:1]([O:8][C:9]1[N:10]=[N:11][C:12]([C:23]#[C:24][C:25]2[CH:30]=[CH:29]C(C(F)(F)F)=CN=2)=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC1N=NC(C#C)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1.[F:59][C:60]1C=CC(I)=[CH:62][C:61]=1[CH3:67]>>[CH2:1]([O:8][C:9]1[N:10]=[N:11][C:12]([C:23]#[C:24][C:25]2[CH:30]=[CH:29][C:60]([F:59])=[C:61]([CH3:67])[CH:62]=2)=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 5211782-Fluoro-5-iodotolueneHCID 712699103,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine2 回HCID 866770253,4-Bis(benzyloxy)-6-ethynylpyridazine2 回

生成物 1

HCID 712703693,4-Bis(benzyloxy)-6-[2-(4-fluoro-3-methylphenyl)ethynyl]pyridazine収率 67%

実験手順

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-fluoro-4-iodo-2-methylbenzene in 67% yield.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-94a8618523ab4b7a8ec572cad712a576
出典データセット
uspto-grants-2016_03
特許番号
US09290456B2

関連ノート

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