Ethyl Acetate → HCID 178436476、化合物

HRID 927153ノート

反応式

HRID 927153 の反応式
OC1C(=O)NN=C(CCC2C=CC=CC=2)C=1.C(OC1N=NC(C(C2C=CC=CC=2)=C)=CC=1OCC1C=CC=CC=1)C1C=CC=CC=1.C([O:54][C:55]1[N:56]=[N:57][C:58]([C:69]([C:71]2[CH:76]=[CH:75][C:74]([F:77])=[CH:73][CH:72]=2)=[CH2:70])=[CH:59][C:60]=1[O:61]CC1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>O1CCCC1>[F:77][C:74]1[CH:75]=[CH:76][C:71]([CH:69]([C:58]2[CH:59]=[C:60]([OH:61])[C:55](=[O:54])[NH:56][N:57]=2)[CH3:70])=[CH:72][CH:73]=1

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 86677027HCID 86677027、化合物HCID 86677028HCID 86677028、化合物HCID 1785188083-Hydroxy-6-(2-Phenylethyl)pyridazin-4(1h)-One

生成物 1

HCID 178436476HCID 178436476、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Prepared by the same method as for 4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one (Example 1) from 3,4-bis(benzyloxy)-6-(1-phenylethenyl)pyridazine (Intermediate 41) except that the solvent mixture used for the hydrogenation consisted of ethyl acetate and tetrahydrofuran and the product was recrystallised from a mixture of heptane and MTBE.

後処理

  1. customthe product was recrystallised from a mixture of heptane and MTBE

出典と根拠

ORDレコード
ord-384b6d643a5a474aa5c6113f9ccd9594
出典データセット
uspto-grants-2016_03
特許番号
US09290456B2

反応ノート

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