6-Cyclohexenyl-pyridine-2-carboxylic acid → 6-Cyclohexyl-pyridine-2-carboxylic acid

HRID 927343ノート

反応式

HRID 927343 の反応式
[C:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>C(O)C.[Pd]>[CH:1]1([C:7]2[N:12]=[C:11]([C:13]([OH:15])=[O:14])[CH:10]=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

4

反応物 1

HCID 710872336-Cyclohexenyl-pyridine-2-carboxylic acid

生成物 1

HCID 681621566-Cyclohexyl-pyridine-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 6-cyclohexenyl-pyridine-2-carboxylic acid (0.8 g, 3.94 mmol) in ethanol (50 mL) was added 10% palladium on carbon (20%, 0.16 g) under an atmosphere of nitrogen. The suspension was degassed under vacuum and exchanged with hydrogen several times. The mixture was stirred under hydrogen balloon at ambient temperature overnight. The reaction mixture was filtered through a pad of celite, the pad was washed with ethanol and the combined filtrates were concentrated to dryness. The crude title compound (0.62 g, green oil) was used for the next reaction step without further purification; MS (EI): m/e 206.2 [M+H]+

後処理

  1. customThe suspension was degassed under vacuum
  2. filtrationThe reaction mixture was filtered through a pad of celite
  3. washthe pad was washed with ethanol
  4. concentrationthe combined filtrates were concentrated to dryness
  5. customThe crude title compound (0.62 g, green oil) was used for the next reaction step without further purification

出典と根拠

ORDレコード
ord-c5b7db4d7b3649f38cba0c072bdf07f4
出典データセット
uspto-grants-2016_03
特許番号
US09290451B2

反応ノート

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