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Methanol → 5-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((-)-methylcarbamoyl-phenyl-methyl)-amide

HRID 927666
ノート
印刷プレビュー

反応式

HRID 927666 の反応式
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][C@H:20]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:21]([NH:23][CH3:24])=[O:22].CO>CCCCCCC>[CH3:24][NH:23][C:21]([CH:20]([NH:19][C:15]([C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)=[O:17])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 887MethanolHCID 71087301(2R)-2-amino-N-methyl-2-phenylacetamide hydrochlorideHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

生成物 1

HCID 780121885-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid ((-)-methylcarbamoyl-phenyl-methyl)-amide

試薬・触媒・溶媒 1

HCID 8900Heptane溶媒

実験手順

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethyloxy-pyridine-2-carboxylic acid (Example 42 a) and (αR)-α-amino-N-methyl-benzeneacetamide hydrochloride (1:1) (CAN 97549-10-5) as starting materials. Racemization occurred during the synthesis and the product was isolated by chiral chromatography on Chiralpak AD using heptane/20% ethanol as eluent. The (−)-enantiomer was isolated. LC-MS (UV peak area/ESI) 100%, 380.1968 (M+H)+, αD20 (MeOH)=−6.0°.

後処理

  1. customRacemization occurred during the synthesis
  2. customthe product was isolated by chiral chromatography on Chiralpak AD
  3. customThe (−)-enantiomer was isolated

出典と根拠

ORDレコード
ord-684747f5fcc94e758eb0f298e02fb555
出典データセット
uspto-grants-2016_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09290451B2

反応ノート

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