Trifluoroacetic acid → 3-(R)-(3-fluorobenzyl)pyrrolidine
反応式
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=1)[CH2:12][C@@H:13]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]1>C(Cl)Cl>[F:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][CH:27]=1)[CH2:12][C@@H:13]1[CH2:17][CH2:16][NH:15][CH2:14]1参加物
4
実験手順
Trifluoroacetic acid (10 mL) was added to a solution of tert butyl (R)-3-(3-fluorobenzyl)-pyrrolidine-1-carboxylate (Intermediate 99, 0.515 g) in DCM (10 mL) and the mixture was stirred for 1 hour at room temperature. The mixture was evaporated to dryness and the residue was partitioned between DCM and saturated aqueous NaHCO3. The organic extract was separated, dried (MgSO4) and filtered. The filtrate was evaporated to dryness to give 3-(R)-(3-fluoro-benzyl)pyrrolidine (0.402 g) as an oil.
後処理
- customThe mixture was evaporated to dryness
- customthe residue was partitioned between DCM and saturated aqueous NaHCO3
- extractionThe organic extract
- customwas separated
- dry with materialdried (MgSO4)
- filtrationfiltered
- customThe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-9b1b0b3733e54e85933a36e9ecd6bded
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09290472B2
反応ノート
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