benzyl (S)-N-ethylpyrrolidine-2-carboxylate → 1-ethyl-L-Proline

HRID 927986ノート

反応式

HRID 927986 の反応式
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([O:10]CC1C=CC=CC=1)=[O:9])[CH3:2]>[Pd]>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([OH:10])=[O:9])[CH3:2]

参加物

3

反応物 1

HCID 10421496benzyl (S)-N-ethylpyrrolidine-2-carboxylate2 回

生成物 1

HCID 283547181-ethyl-L-Proline収率 102.1%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Palladium on carbon (10%, 0.2 g) was added to a solution of benzyl (S)—N-ethylpyrrolidine-2-carboxylate (Intermediate 107, 0.603 g) under an atmosphere of nitrogen. The mixture was then hydrogenated at 4 Bar for 3 hours. The mixture was filtered through Celite and the filtrate was evaporated to dryness to give (S)—N-ethylpyrrolidine-2-carboxylic acid (0.378 g) as a straw coloured gummy solid.

後処理

  1. filtrationThe mixture was filtered through Celite
  2. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-60b4520823aa4bfca3f3c0544864874b
出典データセット
uspto-grants-2016_03
特許番号
US09290472B2

反応ノート

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