benzyl (S)-1-ethylpyrrolidine-3-carboxylate → (S)-1-ethylpyrrolidine-3-carboxylic acid

HRID 928052ノート

反応式

HRID 928052 の反応式
[CH2:1]([N:3]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10]CC2C=CC=CC=2)=[O:9])[CH2:4]1)[CH3:2]>[OH-].[OH-].[Pd+2].C(OCC)(=O)C>[CH2:1]([N:3]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4]1)[CH3:2]

参加物

4

反応物 1

HCID 71006998benzyl (S)-1-ethylpyrrolidine-3-carboxylate2 回

生成物 1

HCID 28064096(S)-1-ethylpyrrolidine-3-carboxylic acid収率 92%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of benzyl (S)-1-ethylpyrrolidine-3-carboxylate (Intermediate 190, 0.563 g), 20% palladium hydroxide on carbon (0.056 g), ethyl acetate (9 mL) and IMS (1 mL) was degassed and hydrogenated for 4 hours. The catalyst was removed by filtration, washed with ethyl acetate and the filtrate was concentrated in vacuo to give (S)-1-ethylpyrrolidine-3-carboxylic acid (0.318 g) as a solid.

後処理

  1. customwas degassed
  2. customThe catalyst was removed by filtration
  3. washwashed with ethyl acetate
  4. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-49ef22537b6647888a5beaf859bc5552
出典データセット
uspto-grants-2016_03
特許番号
US09290472B2

反応ノート

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