Water → HCID 86713361、化合物
反応式
I[CH2:2][CH3:3].Cl.[NH:5]1[CH2:9][CH2:8][C@@H:7]([CH2:10][C:11]#[N:12])[CH2:6]1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH2:2]([N:5]1[CH2:9][CH2:8][C@@H:7]([CH2:10][C:11]#[N:12])[CH2:6]1)[CH3:3]参加物
6
実験手順
Iodoethane (10.1 g) was added to a mixture of 2-((S)-pyrrolidin-3-yl)acetonitrile hydrochloride (Intermediate 205, 7.9 g) and potassium carbonate (29.7 g) in DMF (20 mL) and the resultant mixture was stirred at room temperature for 5 hours. Water was added and the mixture was extracted with ethyl acetate, washed with brine, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness to give 2-((S)-1-ethylpyrrolidin-3-yl)acetonitrile (3.8 g) as a yellow oil which was used without further characterisation.
後処理
- extractionthe mixture was extracted with ethyl acetate
- washwashed with brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- customThe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-952f120676e841b09856b8d643ef1ad9
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09290472B2
反応ノート
読み込み中…