Cyclobutylamine → HCID 118073613、化合物

HRID 928185

反応式

HRID 928185 の反応式
[CH:1]1([NH2:5])[CH2:4][CH2:3][CH2:2]1.[Cl:6][C:7]1[N:12]=[C:11](Cl)[C:10]([N+:14]([O-:16])=[O:15])=[C:9]([Cl:17])[N:8]=1.CCN(C(C)C)C(C)C>CC(O)C>[Cl:6][C:7]1[N:12]=[C:11]([NH:5][CH:1]2[CH2:4][CH2:3][CH2:2]2)[C:10]([N+:14]([O-:16])=[O:15])=[C:9]([Cl:17])[N:8]=1

参加物

5

反応物 3

HCID 75645CyclobutylamineHCID 81531DiisopropylethylamineHCID 42978432,4,6-Trichloro-5-nitropyrimidine

生成物 1

HCID 118073613HCID 118073613、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

実験手順

Cyclobutanamine (0.485 mL, 5.68 mmol) in iPrOH (20 mL) was added to a solution of 2,4,6-trichloro-5-nitropyrimidine (1.29 g, 5.65 mmol) in iPrOH (40 mL) at −78° C. dropwise via addition funnel. After complete addition, the mixture was allowed to warm to rt over 30 min, then DIEA (0.940 mL, 5.66 mmol) was added and the mixture stirred at rt for 10 min. The solvent was removed under reduced pressure and dried to give the title compound as a pale yellow oil which was used without purification.

後処理

  1. additionAfter complete addition
  2. customThe solvent was removed under reduced pressure
  3. customdried

出典と根拠

ORDレコード
ord-c66db0927f9b4d98b64b1e04e327001f
出典データセット
uspto-grants-2016_03
特許番号
US09290496B2

関連ノート

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