化工社化工社 化学情報印刷レポート · 研究参考用
Thionyl Chloride → 2-(5-Bromo-2-fluorophenyl)-4-Chloropteridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2-(5-Bromo-2-fluoro-phenyl)-3H-pteridin-4-one | HCID 136109958 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-(5-Bromo-2-fluorophenyl)-4-Chloropteridine | HCID 57742381 | 99.3% |
反応手順
Thionyl chloride (371 mg, 3.11 mmol) was added to the stirred suspension of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 (200 mg, 0.623 mmol) in chloroform (5 mL) and dry DMF (100 μL). The reaction mixture was refluxed under nitrogen for 1 h (starting material gone by HPLC). The solvent was removed in vacuo. Then the residue was triturated in Et2O and filtered off to give 210 mg of the title product 106 as a yellow solid (LCMS analysis).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09290502B2 |
| 出典データセット | uspto-grants-2016_03 |
| ORD ID | ord-66c332a926ac4642aa5cca4f7bd70f04 |
| 出典メモ | uspto-grants-2016_03 |