反应详情

Thionyl chloride (371 mg, 3.11 mmol) was added to the stirred suspension of 2-(5-bromo-2-fluorophenyl)pteridin-4-one 104 (200 mg, 0.623 mmol) in chloroform (5 mL) and dry DMF (100 μL). The reaction mixture was refluxed under nitrogen for 1 h (starting material gone by HPLC). The solvent was removed in vacuo. Then the residue was triturated in Et2O and filtered off to give 210 mg of the title product 106 as a yellow solid (LCMS analysis).

1. temperatureThe reaction mixture was refluxed under nitrogen for 1 h (starting material gone by HPLC)
2. customThe solvent was removed in vacuo
3. customThen the residue was triturated in Et2O
4. filtrationfiltered off