Nitric Acid → HCID 90410240、化合物

HRID 928551ノート

反応式

HRID 928551 の反応式
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[OH:12].[N+:13]([O-])([OH:15])=[O:14]>C(Cl)Cl>[Br:1][C:2]1[C:3]([OH:12])=[C:4]([N+:13]([O-:15])=[O:14])[C:5]([N+:9]([O-:11])=[O:10])=[C:6]([F:8])[CH:7]=1

参加物

4

反応物 2

HCID 944Nitric AcidHCID 132681792-Bromo-4-fluoro-5-nitrophenol

生成物 1

HCID 90410240HCID 90410240、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 2-bromo-4-fluoro-5-nitrophenol (4.0 g, 17 mmol) (Ark # AK-27735) in methylene chloride (29.5 mL), 2.0 M nitric acid in methylene chloride (25 mL) was added and the mixture was stirred for 15 min at RT. The mixture was poured into ice-cold water and extracted with methylene chloride to give the crude product, 4.42 g, 93%.

後処理

  1. additionThe mixture was poured into ice-cold water
  2. extractionextracted with methylene chloride

出典と根拠

ORDレコード
ord-a26e386b14e44871ac0fdcce03a2612d
出典データセット
uspto-grants-2016_03
特許番号
US09290514B2

反応ノート

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