Methanol → Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate

HRID 928926

反応式

HRID 928926 の反応式
[Br:1][C:2]1[C:3]([F:20])=[C:4]([F:19])[C:5]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].O=S(Cl)Cl.[CH3:25]O>>[Br:1][C:2]1[C:3]([F:20])=[C:4]([F:19])[C:5]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:25])=[O:8]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 595193885-Bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoic acid

生成物 1

HCID 59519391Methyl 5-bromo-2-(2-fluorophenylamino)-3,4-difluorobenzoate

実験手順

5-Bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoic acid can be reacted with MeOH in the presence of SOCl2 in appropriate solvent. The reaction normally completes within several hours (3-12 h, prefer 5-10 h). Methyl 5-bromo-3,4-difluoro-2-((2-fluorophenyl)amino)benzoate is obtained after conventional workup.

後処理

  1. customThe reaction
  2. waitnormally completes within several hours
  3. custom(3-12 h, prefer 5-10 h)

出典と根拠

ORDレコード
ord-dbaa560b267e478ebddc6d053ee7f5cd
出典データセット
uspto-grants-2016_03
特許番号
US09290468B2

関連ノート

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