Morpholine → 4-(7-Bromoquinoxalin-2-yl)morpholine

HRID 929345ノート

反応式

HRID 929345 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8](Cl)=[N:9]2)=[CH:4][CH:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.C([O-])([O-])=O.[K+].[K+]>CC#N>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[N:9]2)=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 8083MorpholineHCID 11430Potassium CarbonateHCID 49132537-Bromo-2-chloroquinoxaline

生成物 1

HCID 533635264-(7-Bromoquinoxalin-2-yl)morpholine収率 100.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
90 °C

実験手順

To a solution of 7-bromo-2-chloroquinoxaline (50 g, 0.2 mol, 1.0 eq.) in CH3CN (200 mL) were added morpholine (89 g, 1.02 mol, 5.0 eq.) and K2CO3 (85 g, 0.61 mol, 3.0 eq). The resulting mixture was stirred at 90° C. for 2 h, then cooled and filtered. The filtrate was concentrated and the residue was re-crystallized from EA to afford 4-(7-bromoquinoxalin-2-yl)morpholine (59 g, 98.3%).

後処理

  1. temperaturecooled
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated
  4. customthe residue was re-crystallized from EA

出典と根拠

ORDレコード
ord-cc35c464d80e44ea96b8887d47543faf
出典データセット
uspto-grants-2016_03
特許番号
US09295671B2

反応ノート

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