4-Aminobenzoic Acid → 4-amino-N-(oxolan-3-ylmethyl)benzamide

反応式

N1C[CH:3]([O:5][C:6]2[CH:11]=[CH:10][C:9]([NH:12]C(N3CC(C4C=NC=CC=4)C3)=O)=CC=2)C1.[NH2:25][C:26]1[CH:34]=[CH:33][C:29]([C:30]([OH:32])=O)=[CH:28][CH:27]=1.C[C@@H](CC)C(O)=O>>[NH2:25][C:26]1[CH:27]=[CH:28][C:29]([C:30]([NH:12][CH2:9][CH:10]2[CH2:11][CH2:6][O:5][CH2:3]2)=[O:32])=[CH:33][CH:34]=1

参加物

反応物 3

HCID 9784-Aminobenzoic Acid

HCID 448893(S)-2-methylbutanoic acid

HCID 90010911N-(4-(azetidin-3-yloxy)phenyl)-3-(pyridin-3-yl)azetidine-1-carboxamide

生成物 1

HCID 609203514-amino-N-(oxolan-3-ylmethyl)benzamide

実験手順

The title compound was prepared as described in Example 1E, substituting (tetrahydrofuran-3-yl)methanamine for N-(4-(azetidin-3-yloxy)phenyl)-3-(pyridin-3-yl)azetidine-1-carboxamide and 4-aminobenzoic acid for (S)-2-methylbutanoic acid.

出典と根拠

ORDレコード: ord-243adf76918d49b283996143e5090746
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09296723B2

反応ノート

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