Thiazolidine → [5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

反応式

[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([OH:26])=O)[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=C(C2N(C3C=CC=CN=3)N=C(C(N3CC(=O)NC3)=O)C=2)C=C(F)C=1.[S:54]1[CH2:58][CH2:57][NH:56][CH2:55]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:56]3[CH2:57][CH2:58][S:54][CH2:55]3)=[O:26])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:11])([F:12])[F:10])[CH:7]=1

参加物

反応物 3

HCID 10444Thiazolidine

HCID 71576484HCID 71576484、化合物

HCID 89602527HCID 89602527、化合物

生成物 1

HCID 86574477[5-[3-Bromo-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-thiazolidin-3-yl-methanone

実験手順

130 mg (0.30 mmol) of the compound of Example 39A is reacted analogously to the synthesis of the compound of Example 1 with 0.03 ml (0.33 mmol) of thiazolidine. 116 mg (77% of theory) of the title compound is obtained.

出典と根拠

ORDレコード: ord-2d47d9f3014b43a6bbc098c1705e0116
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09296720B2

反応ノート

読み込み中…