m-Chloroperbenzoic acid → [5-[3-Fluoro-5-(trifluoromethoxy)phenyl]-1-(3-pyridyl)pyrazol-3-yl]-(1-oxo-1,3-thiazolidin-3-yl)methanone
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:26]3[CH2:30][CH2:29][S:28][CH2:27]3)=[O:25])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:12])([F:11])[F:10])[CH:7]=1.ClC1C=CC=C(C(OO)=[O:39])C=1>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([C:13]2[N:17]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)[N:16]=[C:15]([C:24]([N:26]3[CH2:30][CH2:29][S:28](=[O:39])[CH2:27]3)=[O:25])[CH:14]=2)[CH:5]=[C:6]([O:8][C:9]([F:10])([F:11])[F:12])[CH:7]=1参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
102 mg (0.23 mmol) of the compound of Example 59 is dissolved in 5 ml of dichloromethane, mixed with 57 mg (0.23 mmol, 70% purity) of meta-chloroperbenzoic acid, and stirred for 16 hours at room temperature. The reaction mixture is concentrated by evaporation in a rotary evaporator, mixed with some acetonitrile, filtered over a Millipore spray filter, and then separated by means of preparative HPLC (mobile solvent: acetonitrile/water gradient). 87 mg (82% of theory) of the title compound is obtained.