HCID 79035731、化合物 → 1-(2-Chloro-3-fluorophenyl)ethan-1-one

温度

0 °C

To a 2L flask was added 2-chloro-3-fluoro-N-methoxy-N-methylbenzamide (41.49 g, 191 mmol) and tetrahydrofuran (800 mL). The solution was cooled to 0° C., then methylmagnesium chloride, 3.0M solution in THF (254 mL, 763 mmol) was added dropwise through addition funnel. The mixture was gradually warmed to 5° C. The reaction was quenched with 5N HCl (190 mL) until it is acidic and extracted with EtOAc twice. The organic solution was washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The crude was purified by flash chromatography on silica gel (330 g, 0-50% EtOAc/hexane in 20 min) to give 1-(2-chloro-3-fluorophenyl)ethanone as a colorless oil (31.3 g, 95% yield). MS m/z=173 [M+H]+. Calculated for C8H6ClFO: 172.6.

1. temperatureThe mixture was gradually warmed to 5° C
2. customThe reaction was quenched with 5N HCl (190 mL) until it
3. extractionextracted with EtOAc twice
4. washThe organic solution was washed with brine
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customThe crude was purified by flash chromatography on silica gel (330 g, 0-50% EtOAc/hexane in 20 min)

ORDレコード

ord-e452042609314e99abb09ae3b8c465ae

出典データセット

uspto-grants-2016_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09296734B2