Thionyl Chloride → 1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl chloride

HRID 930523ノート

反応式

HRID 930523 の反応式
[CH3:1][N:2]1[C:7](=[O:8])[C:6]([CH3:9])=[CH:5][C:4]([C:10]([OH:12])=O)=[CH:3]1.S(Cl)([Cl:15])=O>>[CH3:1][N:2]1[C:7](=[O:8])[C:6]([CH3:9])=[CH:5][C:4]([C:10]([Cl:15])=[O:12])=[CH:3]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 218859251,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

生成物 1

HCID 1178895461,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carbonyl chloride収率 100%

反応条件

温度
60 °C

実験手順

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid D1 (500.000 mg; 2.991 mmol) is suspended in thionyl chloride (2.000 ml; 27.536 mmol) and heated for 2 h at 60° C. The reaction mixture is concentrated under reduced pressure. And used in the next reaction without further purification (Yield: 100%).

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customAnd used in the next reaction without further purification (Yield: 100%)

出典と根拠

ORDレコード
ord-2629e3e720614e108bb7b741e31a794f
出典データセット
uspto-grants-2016_03
特許番号
US09296748B2

反応ノート

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