Benzyl Bromide → 1-benzyl-8-chloro-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one
反応式
[Cl:1][C:2]1[CH:11]=[C:6]2[NH:7][CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:12])[N:3]=1.[H-].[Na+].Br[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CN(C)C=O>[CH2:16]([N:7]1[CH2:8][CH2:9][CH2:10][N:5]2[C:4](=[O:12])[N:3]=[C:2]([Cl:1])[CH:11]=[C:6]12)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1参加物
5
実験手順
To a suspension of 8-chloro-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one (1 g, 2.32 mmol) and sodium hydride (0.28 g, 6.95 mmol) in N,N-dimethylformamide (10 mL) was added (bromomethyl)benzene (0.40 mL, 2.78 mmol) at room temperature, and stirred for 30 min at r.t. Purification via reverse phase column (0.3% TFA in water/acetonitrile) afforded the title compound (300 mg).
後処理
- customPurification via reverse phase column (0.3% TFA in water/acetonitrile)
出典と根拠
- ORDレコード
- ord-cbdc7b93651045e6afec80baab99b81f
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296755B2
反応ノート
読み込み中…