Morpholine → 4-((3-Bromo-4-fluorophenyl)sulfonyl)morpholine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:8].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]([S:9]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[F:8]参加物
4
実験手順
3-Bromo-4-fluorobenzene-1-sulfonyl chloride (0.44 g, 1.609 mmol) in tetrahydrofuran (10 mL) was treated with morpholine (0.294 g, 3.38 mmol). The reaction mixture was stirred for 16 hours at ambient temperature. The solvent was removed, and the residue was loaded onto a silica gel column and eluted with 20% ethyl acetate in hexanes to give the title compound (0.45 g, 1.388 mmol, 86% yield).
後処理
- customThe solvent was removed
- washeluted with 20% ethyl acetate in hexanes
出典と根拠
- ORDレコード
- ord-4ec98ea26d7042daab1e68f869d4ec56
- 出典データセット
- uspto-grants-2016_03
- 特許番号
- US09296741B2
反応ノート
読み込み中…