Lithium hydroxide, monohydrate → 4-bromo-6-methyl-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one

HRID 930954

反応式

HRID 930954 の反応式
[Br:1][C:2]1[C:3]2[CH:12]=[CH:11][N:10](S(C3C=CC(C)=CC=3)(=O)=O)[C:4]=2[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.O.[OH-].[Li+]>O1CCCC1.O>[Br:1][C:2]1[C:3]2[CH:12]=[CH:11][NH:10][C:4]=2[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1

参加物

5

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 896563044-Bromo-1,6-dihydro-6-methyl-1-((4-methylphenyl)sulfonyl)-7H-pyrrolo(2,3-c)pyridin-7-one

生成物 1

HCID 573297664-bromo-6-methyl-1H,6H,7H-pyrrolo[2,3-c]pyridin-7-one収率 94%

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of Example 1e (7 g, 18.36 mmol) and lithium hydroxide monohydrate (3.08 g, 73.4 mmol) in tetrahydrofuran (50 mL) and water (20 mL) was heated at 80° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 300 mL of water. The resulting solid was collected by vacuum filtration to give the title compound (3.92 g, 17.26 mmol, 94% yield).

後処理

  1. filtrationThe resulting solid was collected by vacuum filtration

出典と根拠

ORDレコード
ord-7a9d8b948c364decad089f63777120b0
出典データセット
uspto-grants-2016_03
特許番号
US09296741B2

関連ノート

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