Isopropylamine → (RS)-4-Chloro-N-isopropyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

反応式

[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([OH:17])=O)[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:18][CH:19]([NH2:21])[CH3:20]>>[Cl:1][C:2]1[C:3]2[C:10]3[CH2:11][CH2:12][CH:13]([C:15]([NH:21][CH:19]([CH3:20])[CH3:18])=[O:17])[CH2:14][C:9]=3[S:8][C:4]=2[N:5]=[CH:6][N:7]=1

参加物

反応物 2

HCID 6363Isopropylamine

HCID 179900774-Chloro-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-7-carboxylic acid

生成物 1

HCID 90014840(RS)-4-Chloro-N-isopropyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxamide

実験手順

13.18 g (49.05 mmol) (RS)-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine-7-carboxylic acid (prepared according to intermediate example 31b) were transformed in analogy to example 3 using propan-2-amine to give after working up and purification 11.39 g (71%) of the title compound.

後処理

customto give
custompurification 11.39 g (71%) of the title compound

出典と根拠

ORDレコード: ord-7290af837b1245b1a6ccdca97d62cbad
出典データセット: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09296757B2

反応ノート

読み込み中…

参加物