p-Toluenesulfonic acid → 6-(3-Hydroxyoxetan-3-yl)picolinaldehyde

HRID 931088ノート

反応式

HRID 931088 の反応式
[O:1]1CCO[CH:2]1[C:6]1[N:11]=[C:10]([C:12]2([OH:16])[CH2:15][O:14][CH2:13]2)[CH:9]=[CH:8][CH:7]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[OH:16][C:12]1([C:10]2[N:11]=[C:6]([CH:2]=[O:1])[CH:7]=[CH:8][CH:9]=2)[CH2:15][O:14][CH2:13]1

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 89853573HCID 89853573、化合物

生成物 1

HCID 898538636-(3-Hydroxyoxetan-3-yl)picolinaldehyde

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of 3-(6-(1,3-dioxolan-2-yl)pyridin-2-yl)oxetan-3-ol (67 mf, 0.30 mmol) and p-toluenesulphonic acid (14.8 mg, 0.26 mmol) in acetone (3.00 mL) was heated to 50° C. and stirred for 18 h. The reaction mixture was cooled to room temperature. The solvent was removed under reduced pressure to afford the title compound. The material was used without further purification. MS (ES+) (M+H) 180.0; LCMS retention time: 1.57 minutes (Method L).

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-6f07fe5e01cd4d50a70cd445a0a38a1f
出典データセット
uspto-grants-2016_03
特許番号
US09296745B2

反応ノート

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