Sodium hydride → (S)-2-(2-(benzyloxy)-5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-tert-butoxyethanol

HRID 931809ノート

反応式

HRID 931809 の反応式
C([O:7][CH2:8][C@@H:9]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])[C:10]1[C:11]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)=[C:12]2[C:17](=[CH:18][C:19]=1[CH3:20])[NH:16][C:15](=O)[CH:14]=[CH:13]2)(=O)C(C)(C)C.[H-].[Na+].C([O:40][C@@H:41]([C:45]1[C:46](C2C=CC(Cl)=CC=2)=[C:47]2[C:52](=[CH:53][C:54]=1C)N1N=NN=C1C=C2)C(O)=O)(C)(C)C>CN(C=O)C>[CH2:41]([O:40][C:15]1[CH:14]=[CH:13][C:12]2[C:17](=[CH:18][C:19]([CH3:20])=[C:10]([C@H:9]([O:29][C:30]([CH3:32])([CH3:33])[CH3:31])[CH2:8][OH:7])[C:11]=2[C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[N:16]=1)[C:45]1[CH:46]=[CH:47][CH:52]=[CH:53][CH:54]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 66631890HCID 66631890、化合物HCID 66633768(S)-2-tert-butoxy-2-(6-(4-chlorophenyl)-8-methyltetrazolo[1,5-a]quinolin-7-yl)acetic acid

生成物 1

HCID 66631276(S)-2-(2-(benzyloxy)-5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-tert-butoxyethanol収率 21.7%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To the solution of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-oxo-1,2-dihydroquinolin-6-yl)ethyl pivalate (8J) (16 mg, 0.03 mmol) in DMF (1 mL) was added sodium hydride (7 mg, 60% oil, 0.17 mmol). The mixture was stirred for 30 minutes, and benzyl bromide (64, 0.05 mmol) was added. The mixture was stirred another 90 minutes, and was quenched with water, and left for 12 hours. The mixture was extracted with ethyl acetate, and the organic layer was washed with water and brine, and dried over sodium sulfate. Concentration and purification by flash column chromatography (hexanes/EtOAc) gave (S)-2-(2-(benzyloxy)-5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-tert-butoxyethanol (3.1 mg). LCMS-ESI+ (m/z): [M-FH]+ calcd for C29H30ClNO3: 476.2. Found: 476.1. (S)-1-Benzyl-6-(1-tert-butoxy-2-hydroxyethyl)-5-(4-chlorophenyl)-7-methylquinolin-2(1H)-one was also isolated 6.1 mg LCMS-ESI+ (m/z): [M+H]+ calcd for LCMS-ESI+ (m/z): [M+H]+ calcd for C29H31ClNO3: 476.2. Found: 476.2.

後処理

  1. stirringThe mixture was stirred another 90 minutes
  2. customwas quenched with water
  3. waitleft for 12 hours
  4. extractionThe mixture was extracted with ethyl acetate
  5. washthe organic layer was washed with water and brine
  6. dry with materialdried over sodium sulfate
  7. concentrationConcentration and purification by flash column chromatography (hexanes/EtOAc)

出典と根拠

ORDレコード
ord-76f1d829c8ea452ebaf023100c0e23c4
出典データセット
uspto-grants-2016_03
特許番号
US09296758B2

反応ノート

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