{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester → {4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic Acid

HRID 9345

反応式

HRID 9345 の反応式
C([O:3][C:4](=[O:45])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([S:13][CH2:14][CH:15]=[C:16]([C:29]2[CH:34]=[CH:33][C:32]([C:35]3[CH:36]=[N:37][CH:38]=[CH:39][CH:40]=3)=[CH:31][CH:30]=2)[C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[CH:19][CH:18]=2)=[CH:9][C:8]=1[C:41]([F:44])([F:43])[F:42])C>C(O)C.[OH-].[Na+]>[N:25]1[CH:26]=[CH:27][CH:28]=[C:23]([C:20]2[CH:19]=[CH:18][C:17]([C:16]([C:29]3[CH:30]=[CH:31][C:32]([C:35]4[CH:36]=[N:37][CH:38]=[CH:39][CH:40]=4)=[CH:33][CH:34]=3)=[CH:15][CH2:14][S:13][C:10]3[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([OH:45])=[O:3])=[C:8]([C:41]([F:44])([F:42])[F:43])[CH:9]=3)=[CH:22][CH:21]=2)[CH:24]=1

参加物

4

反応物 1

HCID 69620630{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester

生成物 1

HCID 10326212{4-[3,3-Bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic Acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of {4-[3,3-bis-(4-pyridin-3-yl-phenyl)-allylsulfanyl]-2-trifluoromethyl-phenoxy}-acetic acid ethyl ester (70 mg, 0.1 mmol) in ethanol (10 ml) and 1N NaOH (0.5 ml) was stirred at 75° C. for 1 h. The reaction mixture was evaporated and the residue was treated with 1N HCl (0.7 ml) and extracted with methylene chloride (2×25 ml). The organic phases were dried and evaporated to give the title compound in 23 mg (34%) yield.

後処理

  1. customThe reaction mixture was evaporated
  2. additionthe residue was treated with 1N HCl (0.7 ml)
  3. extractionextracted with methylene chloride (2×25 ml)
  4. customThe organic phases were dried
  5. customevaporated

出典と根拠

ORDレコード
ord-e72a29a49a7e4e14b6c97a72e07036ea
出典データセット
uspto-grants-2006_08
特許番号
US07091245B2

関連ノート

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