Ethoxyacetyl chloride → 7-bromo-2-ethoxymethyl-1-isobutyl-1H-imidazo[4,5-c]quinoline

HRID 9357

反応式

HRID 9357 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:13][CH2:14][CH:15]([CH3:17])[CH3:16])=[C:7]([NH2:12])[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH2:18]([O:20][CH2:21][C:22](Cl)=O)[CH3:19]>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6]3[N:13]([CH2:14][CH:15]([CH3:17])[CH3:16])[C:19]([CH2:18][O:20][CH2:21][CH3:22])=[N:12][C:7]=3[CH:8]=[N:9][C:10]=2[CH:11]=1

参加物

4

反応物 2

HCID 84189Ethoxyacetyl chlorideHCID 688181597-bromo-N4-isobutylquinoline-3,4-diamine

生成物 1

HCID 219843867-bromo-2-ethoxymethyl-1-isobutyl-1H-imidazo[4,5-c]quinoline収率 41.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 7-bromo—N4-isobutylquinoline-3,4-diamine (85 g, prepared according to Part F of Example 1) in anhydrous pyridine (413 mL) was immersed in an ice bath, and ethoxyacetyl chloride (36.9 g, 300 mmol) was added. The reaction was allowed to warm to room temperature and was then heated in an oil bath held at 85° C. for 3.5 h. The reaction mixture was concentrated under vacuum, and the residue was taken up in diethyl ether and washed with 2M Na2CO3 (2×) followed by H2O (1×). The organic layer was dried (MgSO4), filtered, and concentrated. Recrystallization of the resulting solid from boiling 15% ethyl acetate in hexanes afforded 43.0 g of 7-bromo-2-ethoxymethyl-1-isobutyl-1H-imidazo[4,5-c]quinoline as brown crystals.

後処理

  1. temperaturewas then heated in an oil bath
  2. concentrationThe reaction mixture was concentrated under vacuum
  3. washwashed with 2M Na2CO3 (2×)
  4. dry with materialThe organic layer was dried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customRecrystallization of the resulting solid

出典と根拠

ORDレコード
ord-dbeb3e2c5d2e43e88e3b4fdfc8b56049
出典データセット
uspto-grants-2006_08
特許番号
US07091214B2

関連ノート

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